Browsing by Author "Bousbaa, Hassan"

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Mitosis inhibitors in anticancer therapy: When blocking the exit becomes a solution.

Bousbaa, Hassan (2019-10-09)

Current microtubule-targeting agents (MTAs) remain amongst the most important antimitotic drugs used against a broad range of malignancies. By perturbing spindle assembly, MTAs activate the spindle assembly checkpoint ...
Therapeutic targeting of spindle assembly checkpoint silencing as a strategy to sensitize cancer cells to chemotherapy drugs.

Henriques, Ana Cristina do Espírito Santo (2022)

Os agentes anti-microtúbulos (MTAs) têm sido amplamente usados no tratamento do cancro. Ao interferir com a dinâmica dos microtúbulos, levam à ativação do checkpoint mitótico (SAC), provocando uma paragem em mitose. O SAC ...